Level | Definition | Drugs |
---|---|---|
1 a | Drugs should not be coadministered as they might lead to serious adverse events or precipitate opioid withdrawal | Buprenorphine, Tramadol, Nalbuphine, Naloxone, Naltrexone, Amiodarone, Butorphanol, Ciprofloxacin, Chlorpromazine, Cisapride, Dezocine, Dofetilide, Droperidol, Dronedarone, Fentanyl/Droperidol, Fluphenazine, Fospropofol, Gatifloxacin, Halofantrine, Haloperidol, Ibutilide, Iloperidone, Lapatinib, Levofloxacin, Mesoridazine, Moxifloxacin, Nalbuphine, Nilotinib, Paliperidone, Perphenazine, Pimozide, Prochlorperazine, Promazine, Promethazine, Quinidine, Quinine, Ranolazine, Sotalol, Sunitinb, Tapentadol, Telithromycin, Tetrabenazine, Thiethylperazine, Thioridazine, Trifluoperazine, Vardenafil |
2 b | A potential interaction might modify the dosage; monitor closely to minimize clinical consequences | Alprazolam, Estazolam, Flurazepam, Midazolam, Zopiclone, Clormethiazole, Methylphenidate, Amitriptyline, Desipramine, Imipramine, Nortriptyline, Protriptyline, Phenobarbital, Dexamethasone, Fusidic acid, Rifampicin, Spironolactone, Diltiazem, Cimetidine, Dihydroergotamine, Fluconazole, Ketoconazole, Erythromycin, Clarithromycin, Moclobemide, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Risperidone, Merperidine, Alfentanil, Propoxyphene, Morphine, Carbamazepine, Phenytoin |
3 c | Minor or unknown interactions | Dextromethorphan, Nifedipine, Diazepam, Metronidazole, Omeprazole, Verapamil |